Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is an Idiopathic progressive, fatal neurodegenerative disease attacking upper lower motor neurons.

Symptoms typically start between ages 40-60, include twitching, cramping, and loss of motor control in limbs or speech.

The overall majority (90%-95%) of cases are considered sporadic with the rest presenting with a genetic link.

There is no cure, with a typical life expectancy of 3-5 years after diagnosis, though some live 10+ years.

Typical cause of death is respiratory failure.