Transverse Myelitis
Inflammation in a segment of the spinal cord, resulting in demyelination. Symptoms include pain, muscle weakness or paralysis, and bladder or bowel dysfunction. Common triggers include viral or bacterial infections, autoimmune disorders, or other myelin disorders like multiple sclerosis. Management includes corticosteroids, plasmapheresis, rehabilitation. Most recover with residual impairment/disability.
Friedreich’s Ataxia
Friedreich's ataxia (FA) is a rare, autosomal recessive, progressive disorder that causes nerve damage, affecting balance, coordination, and muscle control, along with potential heart, vision, and hearing problems. The condition is caused by a mutation in the FXN gene resulting in an abnormal mitochondrial protein called frataxin.
Symptoms typically begin in childhood or adolescence, with a loss of coordination and walking difficulty, progressing to wheelchair use within 10-20 years. While there is no cure, treatments can help manage symptoms and improve quality of life.
Spina Bifida
Spina bifida is a congenital neural tube defect occurring in the first month of pregnancy when the fetal spinal column fails to close completely, causing nerve damage. It results in varying degrees of paralysis, bowel/bladder dysfunction, and hydrocephalus.
The exact cause is unknown, but it is a combination of genetic, nutritional, and environmental factors, with inadequate folic acid intake before and during early pregnancy being a primary risk factor.
Types
Myelomeningocele: The most severe type the spinal cord and nerves protrude through an opening in the back, resulting in moderate to severe disabilities.
Meningocele: A less common, milder form where the protective sac around the spinal cord pushes through, but the spinal cord itself does not.
Spina bifida occulta: The mildest, most common form ("hidden") where a small gap exists in the vertebrae, usually causing no symptoms or disabilities.